Thursday 6 September 2012

Progression of Vascular Calcification Is Increased With Statin Use in the Veterans Affairs Diabetes Trial (VADT)


  1. Corresponding author: Aramesh Saremi, Aramesh.Saremi@va.gov.

Abstract

OBJECTIVE To determine the effect of statin use on progression of vascular calcification in type 2 diabetes (T2DM).
RESEARCH DESIGN AND METHODS Progression of coronary artery calcification (CAC) and abdominal aortic artery calcification (AAC) was assessed according to the frequency of statin use in 197 participants with T2DM.
RESULTS After adjustment for baseline CAC and other confounders, progression of CAC was significantly higher in more frequent statin users than in less frequent users (mean ± SE, 8.2 ± 0.5 mm3 vs. 4.2 ± 1.1 mm3; P < 0.01). AAC progression was in general not significantly increased with more frequent statin use; in a subgroup of participants initially not receiving statins, however, progression of both CAC and AAC was significantly increased in frequent statin users.
CONCLUSION More frequent statin use is associated with accelerated coronary artery calcification in T2DM patients with advanced atherosclerosis.
  • Received August 8, 2012.
  • Accepted May 23, 2012.

Graham
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2 comments:

  1. Lowcarb team member6 September 2012 at 18:40

    "CONCLUSION More frequent statin use is associated with accelerated coronary artery calcification in T2DM patients with advanced atherosclerosis"

    Great find Graham. Even as a heart job you can see why I keep well away from statins.

    Eddie

    ReplyDelete
  2. Anonymous6 September 2012 at 21:12

    I have commented on statins in another article but I do feel strongly to again stress that you should think twice before taking statins. There is so much evidence that says stay clear.

    Very good item, thank you. Grace

    "CONCLUSION More frequent statin use is associated with accelerated coronary artery calcification in T2DM patients with advanced atherosclerosis"

    ReplyDelete

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