Abstract
Background: Type 2 diabetes is associated with an increase in age-related mortality. A systematic review and meta-analysis were performed to define the relative risks (RR) of all-cause or cause-specific mortality in type 2 diabetes and to determine gaps in current research.
Methods: A comprehensive literature search was undertaken for studies (published 1990–2010) on mortality in type 2 diabetes. The study reports on the measure of mortality as defined by RR for all-cause and cause-specific mortality, heterogeneity, sensitivity analyses and biases.
Results: In total 35 studies (220,689 patients; mean follow-up of 10.7 years) were eligible for inclusion: 33 studies reported increased mortality risks; 24 had full data on 95% confidence intervals (CIs), one study reported no excess mortality in men diagnosed after 65 years whereas three reported increased mortality in similar age groups in both sexes. Meta-analysis showed RR = 1.85 (95% CI 1.79–1.92) for all-cause mortality [men RR=1.57 (95% CI 1.46–1.68); women RR=2.0 (95% CI 1.89–2.12)], RR=1.76 (95% CI 1.66–1.88) for cardiovascular mortality and RR=2.26 (95% CI: 1.7-3.02) for stroke. There was no statistically significant evidence of publication bias.
Conclusion: Type 2 diabetes increases mortality approximately two-fold increase and macrovascular disease is the principal cause of death.
Full text: http://intl-dvd.sagepub.com/
" In those treated with insulin there were worse short- and long-term prognoses after AMI in both sexes"Graham
Yes, Graham, very aptly put "Warning to DCUK members this could be scaremongering and potentially dangerous information, those living in the real world will of course view it differently."
ReplyDeleteI viewed this piece as being very helpful, thanks.
Anonymous said...
ReplyDeleteYes, Graham, very aptly put "Warning to DCUK members this could be scaremongering and potentially dangerous information, those living in the real world will of course view it differently."
I viewed this piece as being very helpful, thanks.
Thanks for your comment, as an adult with T2 I want to know the facts that could affect my well being.
I was warned when newly diagnosed of the consequences high BG, Maybe in the light of recent events at DCUK we should be campaigning to get the NHS to change this information because it could be classed as scaremongering and potentially dangerous information.
Regards
Graham