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Sunday, 20 March 2016

Statin use associated with a 93% increased risk of diabetes

Abstract

Introduction


Data suggest that the beneficial cardiovascular effects of statins are maximized after the first year of statin use; yet, the timeline of statin-associated adverse events is not well delineated.

Objective


To examine the associations of short-term statin use (≤1 year) with short- and long-term adverse events and beneficial cardiovascular outcomes in a ‘healthy’ cohort.

Participants and Methods


A cohort study of a healthy Tricare population (fiscal year [FY] 2002 through FY 2011) who have no cardiovascular disease, major comorbidities requiring medications, or functional limitations. Statin users used statins for 90–365 days during FY 2005 as their only prescription medication. Nonusers had medical encounters but did not receive prescription medications during FY 2005, and did not receive any statins throughout the study period from FY 2002 to FY 2011. Outcomes were the occurrence of major acute cardiovascular events, diabetes mellitus and its complications, kidney diseases, musculoskeletal diseases, obesity, cataracts, malignancy, and death.

Results


We matched 1525 statin users to 1525 nonusers. During the follow-up period (FY 2006 to FY 2011), statin users had significantly higher odds of developing diabetes and diabetic complications that persisted throughout follow-up (odds ratio [OR] 1.93, 95 % confidence interval [CI] 1.55–2.41 and OR 2.15, 95 % CI 1.20–3.86, respectively). Short-term statin use was not associated with decreased odds of major acute cardiovascular events (OR 1.17, 95 % CI 0.72–1.92). There were no differences in risks of kidney diseases, musculoskeletal diseases, or malignancy.

Conclusions


Short-term statin use for primary prevention in this healthy cohort was associated with an increased risk of long-term diabetes and diabetic complications without cardiovascular benefits. Further study using pragmatic studies and prospective observational studies appropriately equipped to eliminate unidentified confounders are urgently needed.


Credit to David Evans for the link @ http://healthydietsandscience.blogspot.co.uk/

Graham

6 comments:

Bob Bushell said...

Well, I didn't know that, thanks.

Margaret-whiteangel said...

Statin is not always a good thing. It made my youngest sister in law very ill.

a writing place said...

Another confusing study...

"A cohort study of a healthy Tricare population (fiscal year [FY] 2002 through FY 2011) who have no cardiovascular disease, major comorbidities requiring medications, or functional limitations. Statin users used statins for 90–365 days during..."

What/where is "a healthy Tricare population"???

If they had "no cardiovascular disease", why were they given statins?????

Isn't there enough logical and well documented information, for posting here?

You have to know, that most people just "skim and swallow" posts. What service are you doing your readers, with such info as this??????

This is the second article, posted here, which has bothered me. You do have one lovely poster. But I think I have to stop reading here.

I don't read posts, to be irritated.

Tessa

Lowcarb team member said...

"This is the second article, posted here, which has bothered me. You do have one lovely poster. But I think I have to stop reading here.

I don't read posts, to be irritated."

With all due respect, no one is forcing you to read this blog or any of the posts. This is a place of free speech, if it is legal it gets posted. We are not a cakes and commiseration club. We intend to keep posting a wide variety of articles, but we are primarily a low carb diabetes forum.

Regards Eddie

chris c said...

Oops!

Lowcarb team member said...

Tessa said...

What/where is "a healthy Tricare population"???

Tricare (styled TRICARE), formerly known as the Civilian Health and Medical Program of the Uniformed Services (CHAMPUS) more here

If they had "no cardiovascular disease", why were they given statins?????

Why indeed it's happening more and more there's even talk of putting children on statins

Isn't there enough logical and well documented information, for posting here?

Having to live 24/7 with diabetes the last thing I want to see is more people developing diabetes which is a life threatening disease, and this was not the first study to reach a similar conclusion with statins.

You have to know, that most people just "skim and swallow" posts. What service are you doing your readers, with such info as this??????

I'm hopefully alerting people to the latest information regarding diabetes, as statins are routinely prescribed to diabetics along with a multitude of side effects this is information pertaining to them

This is the second article, posted here, which has bothered me. You do have one lovely poster. But I think I have to stop reading here.

That is your choice of course but I refer you to the blog title The Low Carb Diabetic which is the main point of this blog

I don't read posts, to be irritated.

What's irritating to you may be seen as informative and helpful for others which is the majority of our readers

Graham