Vitamin D Supplementation Improves Cognitive Function Through Reducing Oxidative Stress Regulated by Telomere Length in Older Adults with Mild Cognitive Impairment: A 12-Month Randomized Controlled Trial
AbstractBackground: Cognitive decline in older adults is a serious public health problem today. Association between vitamin D supplementation and cognition remains controversial.
Objective: To determine whether a 12-month vitamin D supplementation improves cognitive function in elderly subjects with mild cognitive impairment (MCI), and whether it is mediated through the mechanism in which telomere length (TL) regulate oxidative stress.
Methods: This was a double-blind, randomized, placebo-controlled trial in Tianjin, China. Participants were all native Chinese speakers aged 65 years and older with MCI. 183 subjects were randomized to an intervention group (vitamin D 800 IU/day, n = 93) or a placebo group (the matching starch granules, n = 90), and followed up for 12 months. Tests of cognitive function and mechanism-related biomarkers were evaluated at baseline, 6 months, and 12 months.
Results: Repeated-measures ANOVA showed substantial improvements in the full scale intelligence quotient (FSIQ), information, digit span, vocabulary, block design, and picture arrangement scores in the vitamin D group over the placebo group (p < 0.001). Leukocyte TL was significantly higher, while serum 8-OXO-dG, OGG1mRNA, and P16INK4amRNA revealed greater decreases in the vitamin D group over the placebo group (p < 0.001). According to mixed-model repeated-measures ANOVA analysis, vitamin D group showed a significant enhancement in the FSIQ score for 12 months compared with the control (estimate value = 5.132, p < 0.001).
Conclusion: Vitamin D supplementation for 12 months appears to improve cognitive function through reducing oxidative stress regulated by increased TL in order adults with MCI. Vitamin D may be a promising public health strategy to prevent cognitive decline.
Keywords: Cognitive performance; oxidative stress; telomere; vitamin D.
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h/t Marks Daily Apple here
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All the best Jan
All the best Jan
I do take a low dose vitamin D pill and drink milk.
ReplyDeleteI take Vitamin D each day and hope fervently to postpone my cognitive decline.
ReplyDelete...I did take a Vitamin D supplement and after a test my doctor said that I didn't need it.
ReplyDeleteI take vitamin D especially in the winter months and I eat lots of foods rich in vitamin D too.
ReplyDeleteGracias siempre por las buenas informaciones, y por vuestras visitas. Cuidaros.
ReplyDeleteUn abrazo.
All the good foods we eat, good for the brain and soul...xxx
ReplyDeleteI don't take any D supplement - doctor says I don't need to.
ReplyDeleteI don't but...on the other hand, my diet is rich in vitamin D.
ReplyDeleteGood article. Thanx.
ReplyDeleteGod bless.
Laura. M said...
ReplyDeleteGracias siempre por las buenas informaciones, y por vuestras visitas. Cuidaros.
Un abrazo
Google translate
Thank you always for the good information, and for your visits. Take care of yourself.
A hug.
My diet is rich in Vitamin D and I get enough sun. Yet, my vitamin D level was rock bottom. So, I take 50K mg once a week and now the doctor has upped it to once a day at a lower level but still twice the original pill.
ReplyDeleteInteresting to read.
ReplyDeleteLast blood test I had showed I had plenty of Vit D, so I'm lucky :)
Great info and post.
ReplyDeleteI have to take a daily dose of Vitamin D, my doctor keeps an eye on my levels.
I have been really low before. Take care, enjoy your day!
Thanks for the article Jan. I've actually never had my levels tested, but living in Australia I get enough sun, but nice to know that it helps slow mental decline.
ReplyDeleteMy first time visiting here. I take a vitamin D supplement and have for years. I've never discussed it with my doctor, but now I think I will.
ReplyDeleteIt's difficult getting enough sun these days in Canada! We're at -9 this morning!
ReplyDeleteI am outside most days and letting the sun give me the D I need...but it's not enough I can add some of these foods to my diet...Thank you Jan.
ReplyDeleteGood to know about vitamin D - and thanks for the article, list of foods, etc.
ReplyDeleteI take 2,000 units a day and have for sometime after I tested low. I have no idea if it helps anything but my level, but it's easy enough to do!
ReplyDeleteWonderful post. Hubs and I have been taking Vit D since the covid outbreak.xxx
ReplyDeleteWe always have some Vitamin D in the house!
ReplyDelete