However, you might be surprised to discover that paracetamol isn't necessarily appropriate for everyone. In fact, certain people are recommended to speak with a healthcare professional before using this medication to prevent any potential adverse reactions.
The NHS (UK) advises that this particularly applies to anyone who has previously experienced an allergic reaction to medications, including paracetamol, as well as those with a history of kidney or liver conditions.
Additional people who should seek medical guidance beforehand include:
- People who take certain medications
- People with liver or kidney problems
- Anyone who regularly drinks more than the maximum amount of alcohol recommended (14 units per week)
- People who weigh less than 50kg (eight stone) might require a lower dosage
- Anyone who has ever had an allergic reaction to paracetamol or another medicine
Further advice from the NHS explains: "Paracetamol is a common painkiller used to treat aches and pain. It can also be used to reduce a high temperature. It's available to buy from a pharmacy or shop, but you may be able to get 1g tablets on prescription if you have long-term pain.
"It comes as tablets, capsules, syrup, powder that you mix with water, or suppositories. The 1g tablets are only available if prescribed by a doctor. Paracetamol is also available combined with other painkillers and anti-sickness medicines. It is used in a wide range of cold and flu remedies."
Paracetamol is typically safe to take alongside most prescription medicines and antibiotics, though there are certain exceptions. If you've been prescribed warfarin to prevent blood clots, or any medication for epilepsy or tuberculosis, it's best to speak with a doctor before using paracetamol.
When it comes to combining paracetamol with other painkillers, the NHS states: "It's safe to take paracetamol with other types of painkiller that do not contain paracetamol, such as ibuprofen, aspirin or codeine. Do not take paracetamol alongside other medicines that contain paracetamol. If you take two different medicines that contain paracetamol, there's a risk of overdose."
For most adults, the standard dose is two 500mg tablets taken four times within 24 hours, ensuring at least four hours between each dose. You shouldn't exceed eight tablets during this period.
Whilst paracetamol (Ref 1) is generally considered safe for most people, this advice comes after research from the University of Nottingham revealed potential risks associated with long-term use. The study, published in November 2024, cautioned that repeated doses in older patients could heighten the risk of heart, gastrointestinal, and kidney complications.
During their investigation, researchers analysed medical records from 180,483 people aged 65 and above who had been prescribed paracetamol. These were compared against 402,478 people of similar age who hadn't taken the medication.
The findings were concerning, revealing that 'prolonged paracetamol usage' could significantly raise the risk of 'serious complications', including heart failure, high blood pressure, stomach ulcers, and chronic kidney disease. (Ref 2)
As a result, the research team called for a 'careful reconsideration' of prescribing paracetamol (Ref 3) as the first-line treatment for managing long-term pain.
Lead author Professor Weiya Zhang explained at the time: "Whilst further research is now needed to confirm our findings, given its minimal pain-relief effect, the use of paracetamol as a first-line pain killer for long-term conditions such as osteoarthritis in older people needs to be carefully considered."
For more information on paracetamol, visit the NHS website. Always read the packaging for specific instructions on taking drugs like Disprol, Hedex, Medinol, Panadol, and others containing paracetamol as an active ingredient, as instructions may vary.
Words and image above from article seen here
Reference in bracket (1)
In the University of Nottingham, Green Line Link, here in the UK, oral acetaminophen is more generally known as paracetamol.
Reference in bracket (2)In the University of Nottingham, Green Line Link, here in the UK, oral acetaminophen is more generally known as paracetamol.
In America it is my understanding that paracetamol is known in brands such as Tylenol, Mapap and of course generic brands.
Reference in Bracket (3)
It is, of course, important to check what it is known as where you live!
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Articles within this blog (and any comments) are provided for general information only, and should not be treated as a substitute for the medical advice of your own doctor or any other health care professional. Always take account of your personal circumstances, needs, illnesses and medication you may be taking. If you have any concerns about your general health, including medication, you should contact your Doctor / health care provider.
All the best Jan

26 comments:
Dear Jan, thank you for sharing this important information. I rarely take any painkillers. If I have a headache, which thankfully is rare, often a warm shower 🚿 letting the water cascade on my forehead relieves it.
If I have muscle soreness I use an ointment and apply it directly to the area.
...rarely do I need to take painkillers!
I had to look up what this drug was, turns out here in the US we call it Acetaminophen or Tylenol. I didn't realize in some places you can only buy a few tablets at a time. I just bought a Value size bottle of it which contains 500 tablets of 500 mgs each. I buy the same size bottle every other month. My daughter and I both take it all the time. I have arthritis and she has Lupus and Rheumatoid arthritis. While we're both on prescription meds for those things they really only help so much.
I buy 1000 caplets of 200mg Ibuprofen every other month as well.
Gracias por la información. Te mando un beso.
I have to be honest - I am not exactly sure what that is.
My doctor prescribed Meloxicam 15mg
Thanks for this advice-Christine cmlk79.blogspot.com
Interesting read, Jan. Fortunately, I'm ever so lucky for my age.
Great information and post Jan!
Take care, have a great day.
I was surprised when we got to Ireland when they wouldn't sell me more than one box of pain relievers at a time--I think it was ibuprofen. Now I take aspirin when needed, but even that is limited to one box. I think it's an interesting cultural difference. Those things always attract my notice.
I just take Excedrin... lol
hugs
Donna
Great information. Thank you for sharing.
...I almost never take painkillers.
If you're not feeling well, it often helps to just lie down in bed, for example with a heating pad...
But... thank you... this is a great information.
I wish everyone a healthy and happy week.
This is useful information, thanks
This is useful information, Jan, Thank you.
I don't really use it. I use Ibuprofen more, mainly Nurofen as the others have lactose in them and Nurofen doesn't!
I was going to write what Marry wrote. I had to look the med up and I also just bought a bottle of 500 count and 500mgs. I use it with Ibuprofen for lupus pain. Thank you for a great post and how meds are different there compared to the US. Have a great day.
Interesting because Paracetamol is Acetaminophen in the US, brand name Tylenol. This is the pain killer recommended for people over 60.
Thank you for the info
I’m reminded to clear out cold remedies I bought during the pandemic.
May
This is helpful information, Jan. I seldom ever have the need to take painkillers, but I did just this afternoon. I'd been doing climbing and twisting and turning while cleaning out my upper kitchen cabinets and with the arthritis in my spine, I was definitely in need of some relief from the pain. I may take 2 Tylenol in a year's time but today was one of those days that I needed it.
Paracetamol is like a hormone too
I see the paracetamol is what I know as acetaminophen... which I take for arthritis pain. Thanks for the information.
Thank you for this post.
Thankfully I do not need to take painkillers very often.
My mom takes too many, her doctor is trying to find different ways to manage her pain.
Carla
I have to take it when my arthritis medicine is not quite taking the pain away, but I try not to take it for too long.
Interesante reportaje. Alguna vez lo he tomado para la fiebre. Besos.
Useful information about a widely used pain relief that many people have in their medicine cupboard.
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