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Thursday, 17 December 2015

Sugar intake is associated with progression from islet autoimmunity to type 1 diabetes

The Diabetes Autoimmunity Study in the Young

Abstract

Aims/hypothesis

Dietary sugar intake may increase insulin production, stress the beta cells and increase the risk for islet autoimmunity (IA) and subsequent type 1 diabetes.

Methods

Since 1993, the Diabetes Autoimmunity Study in the Young (DAISY) has followed children at increased genetic risk for type 1 diabetes for the development of IA (autoantibodies to insulin, GAD or protein tyrosine phosphatase-like protein [IA2] twice or more in succession) and progression to type 1 diabetes. Information on intake of fructose, sucrose, total sugars, sugar-sweetened beverages, beverages with non-nutritive sweetener and juice was collected prospectively throughout childhood via food frequency questionnaires (FFQs). We examined diet records for 1,893 children (mean age at last follow-up 10.2 years); 142 developed IA and 42 progressed to type 1 diabetes. HLA genotype was dichotomised as high risk (HLA-DR3/4,DQB1*0302) or not. All Cox regression models were adjusted for total energy, FFQ type, type 1 diabetes family history, HLA genotype and ethnicity.

Results

In children with IA, progression to type 1 diabetes was significantly associated with intake of total sugars (HR 1.75, 95% CI 1.07–2.85). Progression to type 1 diabetes was also associated with increased intake of sugar-sweetened beverages in those with the high-risk HLA genotype (HR 1.84, 95% CI 1.25–2.71), but not in children without it (interaction p value = 0.02). No sugar variables were associated with IA risk.

Conclusions/interpretation

Sugar intake may exacerbate the later stage of type 1 diabetes development; sugar-sweetened beverages may be especially detrimental to children with the highest genetic risk of developing type 1 diabetes.

Full study here:  http://link.springer.com/

Graham

4 comments:

Gingi Freeman said...

Have you heard of Andrew Saul?? He has written books like Doctor Yourself... what are your thoughts on his works??? - http://www.domesticgeekgirl.com

chris c said...

This would be interesting to wave in the faces of those clueless Type 1s who claim we have a "lifestyle choice" and not a Real Disease like them. I've seen plenty linking Type 1 to wheat/celiac but not previously sugar. (Does not apply to the (majority? of) Type 1s who are knowledgeable)

Lowcarb team member said...

Agreed Chris and it's not as if there are no obese/overweight T1's

chris c said...

Yup, carb up and shoot up and end up with "double diabetes"