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Thursday 10 January 2013
Recent findings on the health effects of omega-3 fatty acids and statins, and their interactions: do statins inhibit omega-3?
Abstract
Early randomized controlled trials (RCTs) demonstrated the health benefits of omega-3 fatty
acids (n-3), whereas recent RCTs were negative. We now address the issue, focusing on the
temporal changes having occurred: most patients in recent RCTs are no longer n-3 deficient
and the vast majority are now treated with statins. Recent RCTs testing n-3 against
arrhythmias suggest that n-3 reduce the risk only in patients not taking a statin. Other recent
RCTs in secondary prevention were negative although, in a post-hoc analysis separating
statin users and non-users, non-significant protection of n-3 was observed among statin nonusers
whereas statin users had no effect. Recent RCTs testing statins – after the
implementation of the New Clinical Trial Regulation in 2007 – are negative (or flawed)
suggesting that the lack of effect of n-3 cannot be attributed to a parallel protection by statins.
Finally, statins favor the metabolism of omega-6 fatty acids (n-6), which in turn inhibits n-3
and, contrary to n-3, they increase insulin resistance and the risk of diabetes.Thus, n-3 and
statins are counteractive at several levels and statins appear to inhibit n-3.
Full Provisional PDF http://www.biomedcentral.com/content/pdf/1741-7015-11-5.pdf
Graham
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4 comments:
As always there is a good mix of articles to read here, thanks for bringing this to the readers attention.
Jeff
Couldn't agree more with you Jeff.
It's the interesting, sometimes controversial and range of subjects that keeps me looking in.
Sal ( much fitter but still enjoying driving my Ford Fiesta ! )
Thanks for your comments. We try to keep a mix of topics going on here. The page view numbers and comments posted tell us people do not want to read page after page of latest scientific trials etc. We have seen when forums or blogs do not want any boat rockers or argument they rapidly collapse. Just check out Kenny’s forum, Carbos failed forum and David’s long gone forum. Diabetes.co.uk is as dead as a door nail since the boat rockers got banned. Now of course the ETYM people don’t want boat rockers. As I often say, welcome to the crazy world of diabetes.
Eddie
I agree the wide range of articles are very welcome. I used to love the cartoons - if possible more please.
To me this blog has always been like a magazine you can dip in and out of when you have the time, bringing my attention to news and views that interest me.
Hope your Fiesta is running well Sal my Honda serves me well, I find Mercs so passé.
Anne
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