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Friday, 24 July 2015

The relationship between microvascular complications and vitamin D deficiency in type 2 diabetes mellitus

Abstract

Background

Vitamin D deficiency is reported as a possible risk factor for the development of diabetes in several epidemiologic studies. In this study, we investigated the frequency of 25-OH vitamin D deficiency in type 2 diabetes mellitus and the relationship between 25-OH vitamin D deficiency and the prevalence of microvascular complications.


Methods


In this retrospective study, we evaluated the medical records of 557 patients with type 2 diabetes admitted to the Endocrinology Outpatient Clinic from January to March 2010 and 112 healthy controls randomly selected from individuals admitted to the hospital for a check-up and who had a laboratory result for serum 25-OH vitamin D concentrations at screening. The levels of 25-OH vitamin D in patients with type 2 diabetes and the relationship between 25-OH vitamin D deficiency and microvascular complications were investigated.

Results


No significant difference in serum 25-OH vitamin D concentrations was observed between the diabetic and control groups. No correlation was observed between HbA 1C and serum 25-OH vitamin D levels. Serum 25-OH vitamin D levels were lower in diabetic patients with nephropathy, and patients not using any medication, i.e., those treated with dietary changes alone, had a higher prevalence of nephropathy.

Conclusion

Vitamin D deficiency is more common in diabetic patients with nephropathy. When microvascular complications were evaluated, vitamin D levels were found to be lower in patients in whom these complications were more severe. Vitamin D deficiency is therefore associated with microvascular complications in diabetic patients.


Graham

6 comments:

Mike @ A Bit About Britain said...

You're right about the weather!

Roses and Lilacs said...

That is very interesting. I read a study years ago about the benefits of D. One study showed a clear relationship between vit D deficiency and serious falls.

Your mouse story made me smile.

That's alarming about statins causing alzheimers. I take a statin so I need to talk this over with my doctor.

Gloria Baker said...

This is really interesting about vitamine D!
I have to look for my dad he is diabetic!
Thanks!

Lowcarb team member said...

Hello Mike and welcome to our blog. In case other readers are not aware I did comment about our very inclement British weather on several blogs yesterday, including Mike's ... thus his comment. Do hope you will visit the low carb diabetic blog again soon.

In the meantime - stay dry and hope your weekend is going well.

All the best Jan

Lowcarb team member said...

Hi Roses and Lilacs and many thanks for all your comments and thoughts. I can see from your comments you have read a lot of our most recent posts ... from a mouse to Vitamin D to Statins ... quite a variety but so pleased to hear you enjoyed them and found them interesting and beneficial.

Take Care - Enjoy your weekend

All the best Jan

Lowcarb team member said...

Hello there Gloria and many thanks for stopping by. Yes, some of these articles may well be of interest and benefit to your Dad.

We know not everyone who reads this blog is diabetic (I'm not ... but I live the LCHF lifestyle) However, we do always post a range of articles, reports, stories, recipes etc. which we hope readers will find interesting.

I especially love to visit your blog and see your recipe ideas. I do hope you are having a Happy Weekend.

All the best Jan