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Sunday 10 January 2016

Diets with high-fat cheese, high-fat meat, or carbohydrate on cardiovascular risk markers in overweight postmenopausal women: a randomized crossover trial.

Abstract

BACKGROUND:

Heart associations recommend limited intake of saturated fat. However, effects of saturated fat on low-density lipoprotein (LDL)-cholesterol concentrations and cardiovascular disease risk might depend on nutrients and specific saturated fatty acids (SFAs) in food.
OBJECTIVE:

We explored the effects of cheese and meat as sources of SFAs or isocaloric replacement with carbohydrates on blood lipids, lipoproteins, and fecal excretion of fat and bile acids.
DESIGN:

The study was a randomized, crossover, open-label intervention in 14 overweight postmenopausal women. Three full-diet periods of 2-wk duration were provided separated by 2-wk washout periods. The isocaloric diets were as follows: 1) a high-cheese (96-120-g) intervention [i.e., intervention containing cheese (CHEESE)], 2) a macronutrient-matched nondairy, high-meat control [i.e., nondairy control with a high content of high-fat processed and unprocessed meat in amounts matching the saturated fat content from cheese in the intervention containing cheese (MEAT)], and 3) a nondairy, low-fat, high-carbohydrate control (i.e., nondairy low-fat control in which the energy from cheese fat and protein was isocalorically replaced by carbohydrates and lean meat (CARB).
RESULTS:

The CHEESE diet caused a 5% higher high-density lipoprotein (HDL)-cholesterol concentration (P = 0.012), an 8% higher apo A-I concentration (P < 0.001), and a 5% lower apoB:apo A-I ratio (P = 0.008) than did the CARB diet. Also, the MEAT diet caused an 8% higher HDL-cholesterol concentration (P < 0.001) and a 4% higher apo A-I concentration (P = 0.033) than did the CARB diet. Total cholesterol, LDL cholesterol, apoB, and triacylglycerol were similar with the 3 diets. Fecal fat excretion was 1.8 and 0.9 g higher with the CHEESE diet than with CARB and MEAT diets (P < 0.001 and P = 0.004, respectively) and 0.9 g higher with the MEAT diet than with the CARB diet (P = 0.005). CHEESE and MEAT diets caused higher fecal bile acid excretion than did the CARB diet (P < 0.05 and P = 0.006, respectively). The dominant type of bile acids excreted differed between CHEESE and MEAT diets.

CONCLUSIONS:

Diets with cheese and meat as primary sources of SFAs cause higher HDL cholesterol and apo A-I and, therefore, appear to be less atherogenic than is a low-fat, high-carbohydrate diet. Also, our findings confirm that cheese increases fecal fat excretion. This trial was registered at clinicaltrials.gov as NCT01739153.


Graham

3 comments:

Anonymous said...

Many years ago,when he was young and charming
As some of you may know
Graham learnt of cherry farming
Now this was most alarming
For he was young and charming
To be reduced to cherry farming
So many years ago
However could he do it?
No doubt some day he will rue it
Of no doubt there is he knew it
Oh many years ago

Lowcarb team member said...

Well I never we now have an anonymous attempt at poetry, ahh bless nice try but don't give up the day job yet mate !!

Lest we not forget I only pick cherries when they are ripe and the trees are productive

Cherry ripe, cherry ripe,

Ripe I cry,
Full and fair ones
Come and buy.
Cherry ripe, cherry ripe,
Ripe I cry,
Full and fair ones
Come and buy


Kind regards
Graham

chris c said...

Another cherry here.

I DOUBLED my HDL, reduced my trigs to 1/10 of what they were, and while my LDL went up at first, while I was losing the dietician-provided 15kg, then it went back down again. So commonplace as to be unremarkable, so it's good to see studies that describe what actually happens.