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Wednesday, 10 April 2013

Association of Clinical Symptomatic Hypoglycemia With Cardiovascular Events and Total Mortality in Type 2 Diabetes


OBJECTIVE Hypoglycemia is associated with serious health outcomes for patients treated for diabetes. However, the outcome of outpatients with type 2 diabetes who have experienced hypoglycemia episodes is largely unknown.
RESEARCH DESIGN AND METHODS The study population, derived from the National Health Insurance Research Database released by the Taiwan National Health Research Institutes during 1998–2009, comprised 77,611 patients with newly diagnosed type 2 diabetes. We designed a prospective study consisting of randomly selected hypoglycemic type 2 diabetic patients and matched type 2 diabetic patients without hypoglycemia. We investigated the relationships of hypoglycemia with total mortality and cardiovascular events, including stroke, coronary heart disease, cardiovascular diseases, and all-cause hospitalization.
RESULTS There were 1,844 hypoglycemic events (500 inpatients and 1,344 outpatients) among the 77,611 patients. Both mild (outpatient) and severe (inpatient) hypoglycemia cases had a higher percentage of comorbidities, including hypertension, renal diseases, cancer, stroke, and heart disease. In multivariate Cox regression models, including diabetes treatment adjustment, diabetic patients with hypoglycemia had a significantly higher risk of cardiovascular events during clinical treatment periods. After constructing a model adjusted with propensity scores, mild and severe hypoglycemia still demonstrated higher hazard ratios (HRs) for cardiovascular diseases (HR 2.09 [95% CI 1.63–2.67]), all-cause hospitalization (2.51 [2.00–3.16]), and total mortality (2.48 [1.41–4.38]).
CONCLUSIONS Symptomatic hypoglycemia, whether clinically mild or severe, is associated with an increased risk of cardiovascular events, all-cause hospitalization, and all-cause mortality. More attention may be needed for diabetic patients with hypoglycemic episodes.

After five years of lowcarbing I have not experienced a single hypoglycemic event, the simple reason being I don't need  hypoglycemic medications to keep my blood glucose at safe levels. 



Lowcarb team member said...

Never forget Graham 4 is floor LOL.

Brings back memories eh mate !!!!!


Lowcarb team member said...

How could I ever forget fours the floor!!!!!!

Bring on the GlucoTabs.


Anonymous said...

You boys are funny. Fours the floor caused quite a stir I seem to remember. On a serious note I have never experienced problems and I have about 40 carbs a day


Lowcarb team member said...

Kate said.
Fours the floor caused quite a stir I seem to remember.

Yes it did cause a stir Kate, unfortunately most of the comments over a DCUK got deleted, I did copy one though before the mods got to it! Check out the third comment on this blog post "Fours the fllllloooooorrrrr!"