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Sunday, 9 December 2012

Serum Magnesium and Dyslipidemia in Type-2 Diabetes Mellitus !

Hypomagnesaemia is a common feature in patients with type-2 diabetes. It may be a cause or
consequence of diabetes. This study was designed to find out the serum magnesium levels and
its influence on serum lipids, in type 2 diabetics and how it is associated with the duration &
complication of the disease. 45 known diabetic patients and 25 controls were taken for the
study in and around Puducherry. The mean length of time the patients were diagnosed as diabetics
were, 7.28 (± 2.1) years. This period was taken as the duration of disease. The serum
magnesium and HDLc were significantly lowered (p<0.001) and all other lipid profile levels
(TG, TCh, LDLc, VLDLc) were significantly higher (p<0.001) in cases. Our correlation study
revealed a significant negative association between Serum Magnesium (Mg) and fasting plasma
glucose and duration of the disease expressing its role in complication processes. Serum
Mg also depicted significant negative relation with TG and VLDLc (r= -0.519,r = -0.518) and
positive relation with serum HDLc (r =0.741), which explains associative evidence of its role in
dyslipidemia. Our study substantiates the known importance of Mg supplementation in diabetics
to prevent complications.

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