After five years, the primary end point occurred in 1,478 patients (11.8%), of whom 733 had received n-3 fatty acid supplements and 745 had received placebo (11.7% and 11.9% of the total sub-groups respectively), a non-significant difference. Overall, hospital admissions for cardiovascular causes were mainly in patients >65 years, and only 7.7% of patients admitted to hospital for cardiovascular causes died from them during the study.
What this means for GPs
The researchers noted that their results ‘provide no evidence of the usefulness of n-3 fatty acids for preventing cardiovascular death or disease’ in the patients analysed, despite efforts in the study to ‘to optimize medical therapies and control cardiovascular risk factors’.
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