Vaccines are Causing the Epidemics of Type 1 Diabetes, Obesity, and Type 2 Diabetes/ Metabolic Syndrome !

BALTIMORE, Md., Nov. 30, 2012 /NEWS.GNOM.ES-iReach/ — A newly published review in November’s Current Diabetes Reviews  (Nov 1;8(6):413-8) by a scientist at Classen Immunotherapies provides evidence that the epidemics of type 1 diabetes, obesity, metabolic syndrome, and type 2 diabetes are caused by vaccines.

The paper provides a review of evidence that the vaccines are causing the epidemics of insulin dependent diabetes (type 1 diabetes), obesity and non insulin dependent diabetes (type 2 diabetes).  Upon receiving a vaccine some individuals’ immune system becomes hyper active leading to autoimmune destruction of insulin secreting cells. Other individuals produce increased cortisol and other immune suppressing molecules,  to suppress the vaccine induced inflammation. The increased production of cortisol and other molecules leads to type 2 diabetes, obesity and metabolic syndrome.

The evidence supporting vaccines as a cause of the epidemics of obesity and type 2/diabetes metabolic syndrome include the facts:  the epidemic is occurring in other highly immunized mammals including grass fed horses, the epidemic of obesity in humans occurs when children are just 6 months of age, and populations where obesity is the highest actually have some of the lowest rates of type 1 diabetes, an autoimmune disease. The findings explain why the waning of the obesity epidemic in the US is associated with increases in inflammatory conditions as the immune system’s negative feedback loop reaches its maximal limit and additional vaccine induced inflammation goes unchecked.

“The current data shows that vaccines are much more dangerous than the public is lead to believe. Adequate testing has never been performed even in healthy subjects to indicate that there is an overall improvement in health from immunization. The current practice of vaccinating diabetics as well as their close family members is a very risky practice” says the author. “One major problem with vaccines is the “one dose fits all approach”, where in order to induce protection in the 1% with the weakest immune system you are over stimulating the immune system of the remaining 99% of the population and this is leading to epidemics of inflammatory diseases.”

To view published papers and to find out the latest information on the effects of vaccines on autoimmune diseases including insulin dependent diabetes and metabolic syndrome, visit the Vaccine Safety Web site   http://www.vaccines.net/newpage11.htm

http://news.gnom.es/pr/vaccines-are-causing-the-epidemics-of-type-1-diabetes-obesity-and-type-2-diabetes-metabolic-syndrome

More here:

Review of Evidence that Epidemics of Type 1 Diabetes and Type 2 Diabetes/ Metabolic Syndrome are Polar Opposite Responses to Iatrogenic Inflammation.

http://www.ncbi.nlm.nih.gov/pubmed/22934546

Graham

If you tell a lie big enough !

If you tell a lie big enough !

“If you tell a lie big enough and keep repeating it, people will eventually come to believe it. The lie can be maintained only for such time as the State can shield the people from the political, economic and/or military consequences of the lie. It thus becomes vitally important for the State to use all of its powers to repress dissent, for the truth is the mortal enemy of the lie, and thus by extension, the truth is the greatest enemy of the State.” Joseph Goebbels

If you tell a lie long enough and big enough people will come to believe it. Big Pharma and junk food outfits know this. They spend £billions lying 24 hours a day 7 days a week, every week of the year. A very clever trick for the propaganda mobs is to appear to be a government advisory service or charity. A few of the usual suspects, there are many more.

DUK The diabetes charity.

Abbott Bayer Boehringer Ingelheim Bristol Myers Squibb Bupa Bunzl Everyclick First Capital Connect Flora pro.activ Kodak Lilly Lloyds Pharmacy Menarini Merck Serono Morphy Richards
Merck Sharp & Dohme Limited Novartis Novo Nordisk Nursing Times PAL Technologies Ltd Pfizer Rowlands Pharmacies Sanofi-aventis SplendaTakeda Tesco Diets

HEART UK -The Nation’s Cholesterol Charity

Abbott Healthcare Alpro UK AstraZeneca BHR Pharma Cambridge Weight Plan Cereal Partners UK (Sh Wheat) Food & Drink Federation Fresenius Medical Care (UK) Limited Genzyme Therapeutics Hovis Kellogg’s (Optivita) Kowa Pharmaceutical Europe Co Limited L.IN.C Medical Systems Limited Merck Sharpe & Dhome PlanMyFood Pfizer Premier Foods Progenika Biopharma s.a. Roche Products Limited Unilever (Flora) Welch’s (Purple Grape Juice)

The British Nutrition Foundation

However, the organisation's 39 members, which contribute to its funding, include – beside the Government, the EU – Cadbury, Kellogg's, Northern Foods, McDonald's, PizzaExpress, the main supermarket chains except Tesco, and producer bodies such as the Potato Council. The chairman of its board of trustees, Paul Hebblethwaite, is also chairman of the Biscuit, Cake, Chocolate and Confectionery Trade Association.

The European Food Information Council

Current EUFIC members are: AB Sugar, Ajinomoto Sweeteners Europe, Bunge, Cargill, Cereal Partners, Coca-Cola, Danone, DSM Nutritional Products Europe Ltd., Ferrero, Kraft Foods, Mars, McDonald's, Nestlé, PepsiCo, Pfizer Animal Health, Südzucker, and Unilever.

Eddie

GlaxoSmithKline drug turned man into a 'gay sex and gambling addict'

A French appeals court has upheld a ruling ordering GlaxoSmithKline to pay €197,000 (£159,000) to a man who claimed a drug given to him to treat Parkinson's turned him into a 'gay sex addict'.

Didier Jambart, 52, was prescribed the drug Requip in 2003 to treat his illness.

Within two years of beginning to take the drug the married father-of-two says he developed an uncontrollable passion for gay sex and gambling - at one point even selling his children's toys to fund his addiction.

The court heard that Requip's side-effects had been made public in 2006, but had reportedly been known for years. Mr Jambert said that GSK patients should have been informed earlier.

http://www.independent.co.uk/news/world/europe/parkinsons-sufferer-wins-six-figure-payout-from-glaxosmithkline-over-drug-that-turned-him-into-a-gay-sex-and-gambling-addict-8368600.html

NICE still living in a dream world !

With the NHS collapsing into the abyss, the good guys at NICE have the answer to the obesity and type two diabetes epidemics, screen your patients for their exercise activity. Can you imagine some of the conversations. Doctor to 400lb man, how much exercise do you partake in ? This is to a guy that struggled to get from his car to the waiting room, or to get through the door. How about a chat with a slim healthy guy who is struggling to keep a roof over his wife and three kids heads, and working every hour god sends to survive. See my point, another complete waste of time and money, NICE is very good at that.

Obviously some patients will be keep fit fanatics, they have the time and money to join the their local high tech shrine for physical perfection, but the average Joe, forget it. At best he is going to tell his Doctor what he thinks he wants hear, he may even say your having a larf aren’t you, when he points out how many morbidly obese medics he saw down the hospital the day before. He might even ask his Doctor, why Doctors figure so highly on the suicide, alcohol and illegal drug abuse stats so high..

Remember most type two diabetic can’t get a test strip on prescription, testing has been deemed to be a waste of money. You could argue they are right, but only because the dietary advice given to most patients, guarantees a slow progression to ever more medication, and poor control leading to diabetic complication for many. This latest draft guidance published by NICE. will achieve nothing other than waste time and money.

"GPs and practice nurses should screen all adults to determine if they reach recommended levels of physical activity, recommends draft guidance published by NICE.

The guidance says practices should opportunistically use questionnaires to determine the activity of all their adult patients in consultations and tailor advice to those who are not sufficiently active including identifying motivational issues."

Eddie

http://www.pulsetoday.co.uk/20001030.article?sp_rid=mji4mdq1mzg1njus1&sp_mid=40616522&spmailingid=40616522&spuserid=mji4mdq1mzg1njus1&spjobid=169085150&spreportid=mty5mdg1mtuws0#.ULhfi-Qj7Sg

Don't pick up that phone it could be the Statin Police !

Phone Calls, Notes May Boost Statin Adherence

Automated phone reminders followed by letters to patients who did not fill new prescriptions for statin drugs appeared to increase compliance, results of a randomized trial showed.

Among 5,216 patients in the Kaiser Permanente system who failed to fill new statin prescriptions within 1-2 weeks, the drugs were eventually dispensed to 42.3% of those assigned to receive the phone calls and letters, compared with 26% of those receiving no post-prescription outreach (P<0.001), according to Stephen F. Derose, MD, MS, of Kaiser's Southern California office in Pasadena, Calif., and colleagues.

Subsequent refill rates for patients who filled their initial prescriptions were virtually identical in both groups (35.1% in the intervention group versus 35.5% among controls), the researchers reported online inArchives of Internal Medicine.

"This method of population outreach using automated messaging to decrease primary medication nonadherence for a commonly prescribed cholesterol-lowering drug was highly successful," Derose and colleagues concluded.

"The suitability for outreach to large populations makes this an attractive strategy to help reduce the numbers of patients with primary nonadherence" -- that is, those who don't fill their initial drug prescriptions -- "and better target those who remain nonadherent with complementary, more resource-intensive programs," they added.

But in an accompanying commentary, Michael A. Fischer, MD, MS, of Brigham and Women's Hospital in Boston, argued that the intervention's success was modest at best.

"The 16% increase in primary adherence represents an impressive finding, but even with this success, 58% of patients in the intervention group still did not fill their initial statin prescription," he wrote.

"Furthermore, most patients did not refill their statin prescriptions after the initial prescription, revealing the difficulty of achieving sustained improvement in medication adherence."

Fischer suggested that "any given approach will only be able to solve part of the [nonadherence] problem post hoc," meaning that additional tactics need to be developed.

"The next innovations will likely come in the form of prospective tools to assess patients' plans for primary adherence and development of interventions that address individual patients' concerns at the point of prescribing," Fischer wrote.

In the trial, Derose and colleagues looked for patients told to start on statin medications who then did not fill their prescriptions after 1-2 weeks.

Over a 10-week period, the researchers were able to randomize 2,606 to the intervention and 2,610 into the control group. These were out of about 17,000 patients given new statin prescriptions during the period, of whom 65% filled their prescriptions quickly.

The intervention consisted of a phone call asking the patient "to retrieve a personalized message from the health plan," Derose and colleagues explained, which reminded the patient that a statin had been prescribed and described the importance of taking the drug.

When calls went to voicemail, a message was left with a toll-free number to call to retrieve the message. Two more call attempts were made when the automated system detected a busy signal.

Patients in the intervention who still didn't fill the prescription after receiving the phone call or voicemail message were then sent a letter, which reiterated the need to take the medications as prescribed.

The control group was left on its own after the prescription was written, with no reminders or other contact related to filling it.

The primary outcome was prescription fills within 32-39 days of when the prescription was issued. In the case of the intervention group, this was estimated to be 2 weeks after the letter should have been delivered. Patients in the Kaiser Permanente system receive their medications from the health plan, making it unlikely that they filled the prescriptions without the investigators' knowledge.

Expressed as the relative risk for meeting this endpoint, the intervention boosted primary adherence by 63% (RR 1.63, 95% CI 1.50 to 1.76). Changing the time frame for judging whether a prescription was filled to 1 week earlier or 1 week later than in the primary analysis made little difference, Derose and colleagues indicated.

Patients in their 50s responded somewhat better to the intervention than other age groups (P=0.045), but eventual fill rates were significantly better with the intervention relative to control irrespective of age.

Also, having Spanish as the patient's primary language was a significant predictor of adherence regardless of assignment in the trial (odds ratio 1.32, 95% CI 1.06 to 1.65, relative to primarily English-speakers).

Kaiser plans that included a drug benefit also boosted adherence (OR 10.05, 95% CI 6.85 to 14.75, relative to plans without a drug benefit).

Derose and colleagues noted that the intervention was relatively cheap, amounting to about $1.70 per patient.

Limitations to the study included its restriction to patients in the Kaiser Permanente Southern California region, and its use of a definition of primary nonadherence that was somewhat arbitrary and might have influenced the results.

The study was supported by Merck.

Two study co-authors were Merck employees. Other authors and Fischer reported no relevant financial interests.

http://www.medpagetoday.com/Cardiology/Dyslipidemia/36106

Graham

Over 60 MPs Connected to Companies Involved in Private Healthcare !

In total 66 MPs have financial links to companies involved in private healthcare. Of them, 53 are Conservative MPs, 9 are Labour MPs, and 3 are Liberal Democrats, leaving 1 other from another party. This means, 79% of MPs with these links are Conservative.

The interests range in influence from donations made by individuals, shares in a company, or adviser to a company, owner, overseas visits and hospitality, and directorships.

These parliamentarians coupled with the 142 Lords with the same interests, make a total of 206 parliamentarians with financial links to companies involved in healthcare.

All of these public servants were allowed to vote on the Health and Social Care bill, helping it pass into Act.

Recent released research by the Bureau of Investigative Journalism has revealed 124 members of the House of Lords ‘benefit’ from the financial industry.

Several of these Peers are linked to the Healthcare companies and many of these companies will be funding the private healthcare companies that are threatening the very existence of the NHS.

The House of Lords is an open house for companies to attach themselves to key public servants, lobbying and influencing policy that affects are lives.

This list is up-to-date as of May 2012

http://socialinvestigations.blogspot.co.uk/2012/07/over-60-mps-connected-to-companies.html

Becky Hand's articles are generally a load of nonsense.

This post came into us as a comment from a reader. We thought it worthy of a separate thread.

http://thelowcarbdiabetic.blogspot.co.uk/search?q=becky+hand

Becky Hand's articles are generally a load of nonsense. Here is a recent one penned by Becky which links back to this article you've written about above:

http://www.dailyspark.com/blog.asp?post=separating_the_truth_about_carbs_from_the_lies

You'll notice that the article I've linked here is very confrontational in its tone and the words Becky chose. When it was first published, "myths" was actually "lies", but that has been changed since there was a fair bit of complaining going on by some of the SparkPeople members who found it offensive. There was no apology or retraction, it was just quietly changed to "myths" after a couple days of complaining on personal blogs and the SparkPeople message boards.

At the end of that article there is a poll. More than half the people who answered apparently restrict carbs for one reason or another, yet the site insists on pushing these outdated and just plain wrong ideas about carbohydrate intake. Low carb diets are "fad diets", "not sustainable", "unhealthy", "dangerous", you name it....it is really tiresome and demeaning for those of us who have found out that we thrive when we limit our intake of carbohydrates. If we announce any sort of progress we've made, it's not congratulated or seen as being significant. It's always "well, that's water weight" or "that weight will all come right back as soon as you eat some carbs!" etc. The site's "experts" are very attached to the idea that one must eat "heart healthy" grains, and with every meal. If you mention that you don't eat grains and are feeling great/getting healthier because of it, posts will follow accusing you of being disordered, stupid, a liar, etc. and I mean from both the "experts" and the general membership at the site. However nobody has ever been able to explain to me how a cup of any sort of grain is healthier for me than a cup of kale.

Another thing to mention: that article I gave you a link to originally had a comment thread at the bottom where members were respectfully sharing their views. Some were cheering for Becky, while others were complaining about the article as a whole, or about certain points. Some people politely posted links to studies for Becky Hand to read. Well, the comment thread quickly vanished. The entire thing was deleted, with no explanation from Becky or the site. I don't know if this article you linked to had comments on it as well at one time. I suspect it did, and that they too were removed.

It's become very clear to me that SparkPeople is more concerned with their corporate sponsors than they are with providing health and diet information that is actually sane and correct. With that imbalance in mind, I can't recommend the site to friends or family members who are looking for health/weight loss community.

Liver

Everyone loves a good punch up !

Many moons ago when I was at school, nothing fired up the kids more than a play ground punch up. Within seconds of the fight starting, the protagonists could hardly throw a punch, so dense was the surrounding crowd. The teacher had to struggle through the spectators to restore order, and separate the brawlers, happy days. No one ever got hurt, maybe a bloody nose or a split lip, this of course, was in the days before kids carried machete’s and automatic Glocks. The Romans knew a bit about keeping the mob happy, the trouble is people soon get bored watching a couple of guys fighting to the death, before you know it, they want man eating lions in on the act. Do you see my point, how far do you go, and where does it all end ?

Over the years, I have noticed diabetes forums really come alive, when a punch up is in progress The guest count goes up, and the logged in members hits an all time high. Most punters love it of course, but not everyone thinks diabetes forums should be a combat zone. There is always a few that  bleat from the wings, and state ‘any more of this and I will leave the forum, this behaviour is outrageous etc’ They don’t leave the forum, and peace is restored. A few members get banned (almost always lowcarbers) and the forum goes back to being a cakes and commiserations outfit, and a place for the Carboholics and medication addicted, to spread the gloom and misinformation, it was ever thus.

Some say I am the most banned man in the history of UK diabetes forums. I like to think that is true, many of my best friends have been banned from diabetes forums, so I am in good company. As publicised on this blog, we have started a forum of our own, and that presents me with a dilemma. As the UK’s number one forum bad boy, I have to set an example on the new forum, yet I know there is a big demand for the fight club. Hence we have opened this blog up again. Many of our old adversaries, fired forum mods, owners of failed forums, anonymous cowardly blog owners, and other carb addicted miscreants, are history for this blog now. We are looking for new targets, bent MP’s, idiot dietitions, and outfits calling themselves charities, but are really only shills for big pharma or junk food outfits. Experience tells me we won’t have to look very hard.

The weapon of choice for the discerning yobbo.

Eddie

Phillip Lee GP MP wins our greedy bastard of the month award !

Phillip Lee GP MP wins our greedy bastard of the month award !

When Phillip Lee hasn’t got his nose in the trough, he has his head firmly up his backside. This paragon of care and humanity  believes becoming a diabetic is a "lifestyle choice" which makes me wonder does he know the difference between type 1 and type two diabetes ? Not that I believe any type of diabetes was brought about by lifestyle choice. That’s a serious question because the majority of GP’s know almost nothing about diabetes. What compounds the stupidity of the likes of Lee, is when a patient is diagnosed as a type two diabetic, the average Doctor recommends a diet based on carbs which guarantees the patient will be drug dependent and cost the NHS a fortune over the years.

What amazes me with morons and other idiots of Lee’s ilk is that they believe diabetes was brought about by “lifestyle choices” but haven’t got the intelligence to realise type two diabetes can be reversed by “lifestyle choices” thereby saving the cash strapped NHS err…a fortune. OK I will give this guy a break, he does know, but also knows diabetics earn £billions for big pharma. So this is how it works. A Doctor or other medical professional recommends a diet that guarantees the patient requires lots of expensive medication, just as big pharma likes it. He then puts his MP’s hat on and helps destroy and privatise the NHS. He then puts his entrepreneurs hat on, and invests in private healthcare. A win,win,win situation for him. And here is the sickest part of the cunning plan. We pay him a small fortune to shaft us. Yes, we as tax payers pay his salary as a Doctor, we pay his salary as an MP. He then invests his earning in private healthcare and down road we get shafted big time again. Clearly, Phillip Lee is not a stupid as he appears.

"Patients suffering from diseases caused by "lifestyle choices" such as diabetes should pay for their medication to help save the NHS from collapse, a Tory GP urged.

Phillip Lee said the health service could "probably limp on for the rest of this decade" but warned pressure from baby boomers and younger patients, who he accused of being less "stoic" than the war generation, meant the system needs radical reform.

The practising locum and MP for Bracknell said the perception over what was an acceptable complaint to visit a doctor about was "profoundly different" between older and younger patients and claimed the change in attitude meant the NHS was no longer "fit for purpose".

Dr Lee, a member of the Free Enterprise group of Tory MPs, said patients must live healthier lives or help meet the cost of their care from their own pockets.

"If you want to have doughnuts for breakfast, fine, but there is a cost implication down the line," he said."

http://uk.news.yahoo.com/gp-warns-over-lifestyle-illnesses-140556251.html

Eddie

We’ve changed our minds !

After receiving up to 5000 page views a day on this blog over the last week, and getting few views on what we call the captain sensible blog, we are pressing ahead with this blog. Today it’s a few pics of two of my grandchildren, lowcarbers of course. Tomorrow it's back to kicking butt. Look in tomorrow for the latest on an MP who has his nose deep in the trough of greed, and why he believes diabetics deserve all they get and brought it on themselves.

Eddie

Eat to your meter forum and other good sites.

A great new forum run by diabetics for diabetics. Maybe you are not a diabetic but need some help or advice for a family member or friend. Maybe you are looking for some weight loss ideas. Whoever you are and wherever you are, and what ever method you use for the safe control of your diabetes, you will be warmly welcomed.

Go to the link and press forum 

http://www.eattoyourmeter.org/

Face book page

http://www.facebook.com/EatToYourMeter

A website set up for the newly diagnosed aimed at non insulin using diabetics

http://www.lowcarbdiabetic.co.uk/

A blog posting diabetes news, comment and useful information for all diabetics

http://www.lowcarbdiabeticuk.blogspot.co.uk/

A blog posting recipes, food ideas and links to good food information

http://www.lowcarbdietsandrecipes.blogspot.co.uk/

The Last Post.

Apart from linking to the new forum, our two other blogs and our diabetes website, this will be the last post on this blog. The reasons for it’s continuance no longer exist. It was set up to give people a voice, a voice that was denied elsewhere. We now have the new forum and our other blogs. This blog was also set up to take on tyrannical and idiotic forum moderators. With help from some good friends, we brought about the downfall of the worst offenders. These and other miscreants hang around on other forums and blogs. Their main roll seems to be ridiculing good people (present company exempted) and posting lies. Carbo once said “if my employer found out this blog was mine I would lose my job” or words to that effect, hence his need for staying anonymous. Says all you need to know about the man and his followers.

One blog will be a place to read useful and current diabetes comment and news. The other offering recipes, good food information and links to good food sites. We also have our website. Thank you to all the people that took the time to read our posts, and post your positive comments.  When we started this blog a few years back, we hoped to get a hundred people or so a month read it. Last week in one day we received over 2700 page views. In the first 18 days of November 29462 page views, thank you again for your precious time, you the readers made this blog work. We will be checking on this blog from time to time, for any positive comments you may wish to make, thank you for your time. A special thank you to my co editors Graham and John, without them it would never have got off the ground.

As you would expect, our fight against dietary stupidity, and poor diabetes information, that has caused the early death of millions of diabetics goes on. Please look in on the new forum and our other blogs. Why not join the forum and make a real difference. You could help a person keep their eyesight, keep their limbs and kidney function, all it takes is a little bit of your time. Other diabetics and forum posters saved our small team from the grim outcomes poorly controlled diabetes can bring, you can do the same for others.

Good luck and health to you and yours.

Eddie Mitchell

The Chain Fleetwood Mac

The Formula One seasons drawing to a close! so one of my favourite Fleetwood Mac tracks:


Graham

Stiff Upper Lip - AC/DC

This one’s for me. If you are gonna take on idiots, drug shills, junk food pushers, and lowcarb antis year after year, you need a stiff……stiff upper lip ! Eddie

For my great friend John.

Two Songs by Bukka White

Chris Botti,Midnight Without You-With Paul Buchanan.

One of my favourite musicians. A great track with some stunning photographs of truly mesmerising women. Eddie

Shirley Bassey - The Living Tree.

The best at her very best. A true super star, 50 years into her career and she can still fill any concert hall in the world. Eddie

A great new diabetes forum and it's happy days. Big mama Thornton "Oh, Happy day" Eddie

Saturday night is music night.

Just got a request in from a guy called Dick, he wants to dedicate this to his good friend Carbophile.

Fasting cholesterol tests 'not needed'

GPs do not need to ask patients to fast before taking a cholesterol test as it makes very little difference to the results, a large-scale study has suggested.

Canadian researchers found that mean levels of total cholesterol and HDL-cholesterol varied by less than 2% among individuals with fasting times of between one and 16 hours.

The researchers concluded fasting for routine lipid levels was ‘largely unnecessary’, contradicting best practice as recommended by NICE and the Joint British Societies.

Their study looked at the laboratory results of blood samples from 111,048 women and 98,132 men in the community and cross-referenced this with the duration they had fasted before the sample was taken.

The data was from a six-month period in 2011 and researchers controlled for the differing age of patients. They then estimated the mean levels of cholesterol subclasses recorded at different fasting times.

The mean levels of total cholesterol and HDL-cholesterol differed little among individuals with various fasting times, with variations of less than 2%.

http://www.pulsetoday.co.uk/20000896.article?sp_rid=MjI4MDQ1Mzg1NjUS1&sp_mid=40557199&spMailingID=40557199&spUserID=MjI4MDQ1Mzg1NjUS1&spJobID=167558006&spReportId=MTY3NTU4MDA2S0#.UKbFuuQj7Sg

Six-monthly HbA1c tests in diabetes 'unnecessary'

GPs do not need to test blood glucose in patients with stable diabetes every six months, as recommended by NICE, as it leads to a high rate of false positives an NHS report has concluded.

Annual monitoring would give more meaningful information on changes to HbA1c which for most people happen quite slowly, the NHS Diabetes report said.

Statistical modelling showed for patients whose HbA1c is currently 56mmol/mol, six-monthly monitoring would pick up 405 positive tests per 1,000 patients – that is HbAlc readings above 58.5 mmol/mol - but 28% of those would be due to measurement variation and not a real increase.

For the same group of patients annual monitoring would pick up 479 per 1,000 patients but with only 16% would be false positives, the University of Oxford researchers who did the analysis found.

In other groups with lower starting HbA1c readings most of the positive tests seen with six-monthly tests would be false positives, the report said.

For someone with a starting HbA1c, a positive test six months later has a 64% chance of being false compared with 31% after a year, the figures showed.

‘For many people with diabetes, six-monthly monitoring is more likely to yield a false-positive test – attributable to the within-measurement variability of HbA1c – than a true-positive test, attributable to the change over time in glycaemic control,’ the researchers concluded.

‘Annual monitoring gives more time for a meaningful change to occur in HbA1c.’

http://www.pulsetoday.co.uk/20000846.article?sp_rid=mji4mdq1mzg1njus1&sp_mid=40536833&spmailingid=40536833&spuserid=mji4mdq1mzg1njus1&spjobid=167218515&spreportid=mty3mje4nte1s0#.UKbFBeQj7Sg

US biopharma: 221 drugs now in R&D for diabetes, related conditions !

WORLD NEWS | NOVEMBER 14, 2012
LYNE TAYLOR

US biopharmaceutical research companies are currently developing a total of 221 new medicines for the treatment of diabetes and related conditions, according to new industry data.

All these new treatments are either in clinical trials now or awaiting approval by the US Food and Drug Administration (FDA), says a new report from the Pharmaceutical Research and Manufacturers of America (PhRMA).

They include 32 new treatments for type 1 diabetes, 130 for type 2, 14 for unspecified diabetes and 64 for diabetes-related conditions, says PhRMA, which describes this pipeline as "an exciting new chapter in the ongoing quest to better treat this debilitating disease."

Since 1990, six new classes of diabetes type 2 medicines have been approved by the FDA. The products which are currently in development include: - a once-daily medicine that selectively inhibits the protein associated with glucose metabolism; - a medicine designed to inhibit an enzyme linked to diabetic neuropathy; and - a medicine used to treat type 2 diabetes that may allow for once-weekly dosing.

25.8 million people in the US - nearly 8.3% of the population - have diabetes, says PhRMA. An estimated 18.8 million of these people have been diagnosed, but seven million are not aware that they have the disease, and another 79 million have pre-diabetes.

And as many as one in three US adults could face the disease by 2050 if current trends continue, according to the US Centers for Disease Control and Prevention (CDC). The prevalence is expected to rise sharply for a variety of reasons, including an ageing population more likely to develop type 2 diabetes, increases in minority groups at high risk for the disease, and longer lifespans among diabetes patients. 

If untreated, the condition can lead to severe health problems and complications, such as heart disease, stroke, vision loss and amputation, notes PhRMA, which also points out that average medical expenditures among people with diagnosed diabetes are 2.3 times higher than such spending for people who do not have the disease.

The industry group also discusses the significant economic consequences of diabetes, which in 2007 totalled $174 billion in the US. $116 billion of this was accounted for by direct medical costs, while indirect costs (including disability, work loss and premature mortality) came to $58 billion. If the additional costs of undiagnosed diabetes ($18 billion), pre-diabetes ($25 billion) and gestational diabetes ($623 million) are factored in, the total annual cost of diabetes in the US amounts to $218 billion, it says.

However, improved adherence to diabetes medications can lead to better health outcomes and reduced costs, PhRMA notes. Recent research suggests that patients with diabetes who do not consistently take their medicines as prescription are 2.5 times more likely to be hospitalised than those who follow their prescribed treatment regimens more than 80% of the time.

Also, a recent study in the journal Health Affairs projected that improved adherence to diabetes medications could result in more than 1 million fewer emergency room visits and close to 620,000 less hospitalisations annually, giving total potential savings of some $8.3 billion a year.

http://www.pharmatimes.com/Article/12-11-14/US_biopharma_221_drugs_now_in_R_D_for_diabetes_related_conditions.aspx

Graham

Vitamin D Deficiency For Diabetics Can Lead To Clogged Arteries !

Vitamin D Suppression of Endoplasmic Reticulum Stress Promotes an Antiatherogenic Monocyte/Macrophage Phenotype in Type 2 Diabetic Patients*

Capsule

Background: Interactions between environmental conditions and monocyte phenotype are critical for the development of vascular complications in diabetes.

Results: Modulation of ER stress by vitamin D controls monocyte/macrophage phenotype and vascular adhesion.

Conclusion: Vitamin D is a natural ER stress reliever that promotes an anti-inflammatory monocyte/macrophage phenotype.

Significance: Vitamin D is a potential therapy to reduce vascular complications in diabetics.

Abstract

Cardiovascular disease is the leading cause of morbidity/mortality in patients with type 2 diabetes mellitus (T2DM), but there is a lack of knowledge about the mechanism(s) of increased atherosclerosis in these patients. In patients with T2DM, the prevalence of 25-hydroxy vitamin D (25(OH)D) deficiency is almost twice that for nondiabetics and doubles the relative risk of developing cardiovascular disease compared with diabetic patients with normal 25(OH)D. We tested the hypothesis that monocytes from vitamin D-deficient subjects will have a proatherogenic phenotype compared with vitamin D-sufficient subjects in 43 patients with T2DM. Serum 25(OH)D level inversely correlated with monocyte adhesion to endothelial cells even after adjustment for demographic and comorbidity characteristics. Vitamin D-sufficient patients (≥30 ng/ml 25(OH)D) had lower monocyte endoplasmic reticulum (ER) stress, a predominance of M1 over M2 macrophage membrane receptors, and decreased mRNA expression of monocyte adhesion molecules PSGL-1, β₁-integrin, and β₂-integrin compared with patients with 25(OH)D levels of <30 ng/ml. In vitamin D-deficient macrophages, activation of ER stress increased adhesion and adhesion molecule expression and induced an M2-predominant phenotype. Moreover, adding 1,25(OH)₂D₃ to vitamin D-deficient macrophages shifted their phenotype toward an M1-predominant phenotype with suppressed adhesion. Conversely, deletion of the vitamin D receptor in macrophages from diabetic patients activated ER stress, accelerated adhesion, and increased adhesion molecule expression. The absence of ER stress protein CCAAT enhancer-binding protein homologous protein suppressed monocyte adhesion, adhesion molecule expression, and the M2-predominant phenotype induced by vitamin D deficiency. Thus, vitamin D is a natural ER stress reliever that induced an antiatherogenic monocyte/macrophage phenotype.

http://www.jbc.org/content/287/46/38482

More Here:

http://www.medicalnewstoday.com/articles/252821.php

Use of antidepressants and the risk of type 2 diabetes mellitus: a nested case-control study.

Khoza S, Barner JC, Bohman TM, Rascati K, Lawson K, Wilson JP.

Source

Department of Clinical Pharmacology, College of Health Sciences, University of Zimbabwe, PO Box A 178, Avondale, Harare, Zimbabwe. skhoza53@gmail.com

Abstract

BACKGROUND:

Recent evidence from case reports, observational studies, and randomized trials suggests that long-term use of antidepressants increases the risk of developing diabetes. However, the nature of the relationship between antidepressants and diabetes remains unclear.

OBJECTIVE:

To determine whether there is an association between antidepressant use and the risk of developing type 2 diabetes mellitus.

METHODS:

A nested case-control study using the Texas Medicaid prescription claims database was conducted. Data were extracted for new users of either antidepressant agents (exposed) or benzodiazepines (unexposed) from January 1, 2002 through December 31, 2009. Patients aged 18-64 years without a history of diabetes were included in the cohort. The adjusted odds ratio (OR) and 95% confidence interval (CI) for the risk of diabetes associated with antidepressant exposure was computed using conditional logistic regression, controlling for demographic and clinical covariates.

MAIN OUTCOME MEASURE:

Development of type 2 diabetes mellitus.

RESULTS:

Among the total sample (N = 44,715), the majority were in the exposed (N = 35,552) vs. the unexposed (N = 9,163) group. A total of 2,943 cases of type 2 diabetes mellitus and 11,748 matched controls (1:4) were identified using risk-set sampling. Cases and controls were matched using age and gender. Antidepressant use was associated with an increase in the risk of (type-2) diabetes when compared to benzodiazepine use [Adjusted Odds Ratio (OR) = 1.512; 95% CI 1.345-1.700]. The association was observed with serotonin-norepinephrine reuptake inhibitors (OR = 1.742; 95% CI 1.472-2.060), tricyclic antidepressants (OR = 1.533; 95% CI 1.295-1.814), selective serotonin reuptake inhibitors (OR = 1.457; 95% CI 1.279-1.659), "Other" antidepressants (OR = 1.318; 95% CI 1.129-1.540).

CONCLUSIONS:

Antidepressant use was associated with an increased risk of (type-2) diabetes. This association was observed for tricyclic antidepressants, serotonin-reuptake inhibitors, serotonin-norepinephrine reuptake inhibitors, and other antidepressants.

http://www.ncbi.nlm.nih.gov/pubmed/22249783

Graham

diabetes.co.uk heading for the rocks ?

itching

by basketcase1002 » November 1st, 2012, 2:48 am

Hi, I've only just been diagnosed and I fancied a bit of chocolate before bed tonight but had 3 chunks instead of the usual 1. After a couple of hours sleep I woke up itching all over like a demented pig, I also had a pain in the pit of my stomach. I am assuming all this is down to the chocolate. What can anyone tell me and what causes the itching? Thanks.

Top

m

Re: itching

by PC@Signalvsnoise » 13 minutes ago

Even though you are newly diagnosed I was wondering if you are on any medication as this could be a side effect. Itching after eating food could also be a sign of an allergic reaction. How have you been since? Also do you regularly eat this brand of chocolate?

!79 views and the OP 4 post made waits 15 days for a newbie to answer on his first post. So much for help on this forum.

The Silence Of The Spams !

Carbo tries to wind me up !

Oh no Carbo, your ham fisted riposte just won’t do, I had expected so much more from you. Do you think you can dissect me with your fly blown blog. You know what you look like to me Carbo, with your bag of do-nuts and packets of hobnobs? You look obese, overweight, and a high carb low fat failure. Good nutrition’s given you some length of bone, but too many carbs have lead to your downfall. You’re not more than one Jammie Dodger from your next hyper, are you, Carbo.

Carbo, and that accent you've tried so desperately to shed, pure West Brom. You know how quickly the tuck shop found you, all those tedious sticky fumblings at the back of the class, with crispy cream do-nuts and chocolate digestives, While you could only dream of getting out…... Getting…anywhere.….getting all the way…….to the weight watchers club.

A low carb anti, once tried to test me, I ate his liver with some fava beans and a nice Chianti.

Tell me Carbo why was you fired as a mod from DCUK, Don’t lie because I will know. Err Err I was a useless mod and pissed off too many people. And why did your forum sink without trace. Err  Err people could see through us and wouldn’t buy the eat the carbs to your meter goes off the scale bull shit.

First principles, Carbo. Simplicity. Read Marcus Aurelius. Of each particular thing ask: what is it in itself? What is its nature? What do you do, what do you seek? Err sticky buns, NO ! What is the first and principal thing that drives you? Toast. NO !, err heroic amounts of toast, NO !, that is incidental. You covet, that is your nature. And how do we begin to covet, Carbo ? We covet with our eyes. What needs do you serve by eating? Anger, um, social acceptance, and, huh, sexual frustrations, NO, We begin by coveting what we see every day. Don't you love eating those Mars bars and chocolate digestives Carbo? and don't your eyes seek out the things you want ? Err yes.

Why do you hide out like a gutless anon on your blog, encouraging dullards and wasters to bad mouth good people. Winding up the lowcarb diabetic blog boys is understandable, but why the others ?

Err I haven’t even got the courage to post as an anon and say what I think, so I let others do my dirty work.

Do you want to be helped Carbo ? Yes I need help, I’m becoming a fruit cake. That has been your downfall Carbo too many cakes, biscuits and toast. What can I do ?

Look for severe childhood disturbances associated with roast spuds, rice, and toast. You wasn't born a glutton, and an anti lowcarber Carbo. You was made one through years of systematic sugar and starch abuse. You hate your own identity, you see, and you think if you can bring every newbie and confused diabetic down to your level, you will feel good about yourself. That you won‘t wake up in the middle of the night, screaming and craving toast, you won’t be the only one raiding the biscuit barrel, and shovelling pies and cakes down your neck, you won't be the only one, that can’t say no, to a fried Mars bar. Am I right, or am I right?

You are right Eddie.Thank you Carbo.

Carbo check these guys out they can help you http://www.eattoyourmeter.org/

Carbo One more thing, hate ya suit!

Harry Enfield - Self Righteous Brothers

Pancreas Stem Cell Discovery May Lead to New Diabetes Treatments !

Stem cells in the adult pancreas have been identified that can be turned into insulin producing cells, a finding that means people with type 1 diabetes might one day be able to regenerate their own insulin-producing cells.

The discovery was made by scientists from the Walter and Eliza Hall Institute and provides further evidence that stem cells don't only occur in the embryo.

Dr Ilia Banakh and Professor Len Harrison from the institute's Molecular Medicine division have not only identified and isolated stem cells from the adult pancreas, but developed a technique to drive these stem cells to become insulin-producing cells that can secrete insulin in response to glucose.

http://www.sciencedaily.com/releases/2012/11/121114113452.htm

Tinker Tailor Liar Troll part 1 The Directors cut !

Karla sat in her safe house flat and watched the sun rising over Brondesbury Park. How had it gone so wrong she thought. Four years of planning, treachery and betrayal all for nothing. The plan was brilliant, she had planned every move down to the smallest detail. She had infiltrated the lowcarb team, with a cunning plan. She had praised the lowcarb team, indeed she had even left forums in support of the team. After a making a cup of tea and given her hobnob a good dunking, she pondered further. She realised her vicious and cowardly attack on a friend of the team had been a massive error of judgement, and was the start of her unravelling. The team had held suspicions for a long time, but now she had completely blown it. Exiled by the team, a new plan was required. Banned at the big forum, and her sock puppet trollery had taken the lowcarb forum out, there was only one place left. The last bastion of the failed and disgraced, Carbo’s cess pit. She would also rejoin the big one under a new name and bide her time.

Knowing it was the hang out of the low carb anti’s she would have to work hard to win them over. She quickly realised they would accept anyone that rubbished Eddie and the team, much to her amazement they even stated they had forgiven her. Karla smiled to herself when she thought how easy Carbos crew had been taken in. Phase two of her new plan was a master stroke, get some of the anonymous ones to start posting on Carbo’s blog using their forum names. Even she had admitted to herself the plan was daring, and not foolproof, could she pull off one last big coup d’état. Within hours Phoenix, Jopar and the cherub had outed themselves. As she put the kettle on and opened her jar of kefir, she laughed out and almost screamed with orgasmic pleasure, how could they have been so dumb she thought. The cherub and Jopar yes, but the member code named the intellectual, this was more than she dared hope for. The intellectual long regarded as the most slippery anti in the known world, had actually posted on Carbo’s blog. How desperate the antis must be she thought. What credibility did they have left.

While the glove puppets, Bonkers and Knobhead had been bleating on about gruesome blogs and forums on the big one, had these dullards forgotten they were the first joiners of the Kenny boys home of misinformation and self adulation. She fell into hysterical laughter when it dawned on her, she had started the destruction of Kenny boy, and there he was trolling again at the big one, the very forum Kenny boy had banned her from, during what became known as ' The Reign of Terror’ She had sowed the seeds of Kenny’s demise, but it was beyond her wildest dreams, to see he had blown out what remained of his brains, yet again.

She was beside herself with joy, as she opened her favourite brand of Austrian chocolates. The big one she had infiltrated was in uproar, thread locking and post deletion, was on the way back to the ‘fat ex copper that used to be a mods days’ The dullards had fell for her ‘They think they know who I am' but, the old it’s my employees name and address’ ruse seemed to have worked, and life was looking sweet. Carbo and his miscreants were rubbishing all sorts of  people, posting lie after lie anonymously, but making mistakes she would never have made. While tucking into her second packet of hobnobs, she weighed up her options. Should she sit back and watch the mayhem, or should she try and infiltrate the new forum.

To be continued.