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Sunday, 3 March 2013

More on gut flora and diabetes.


A recent study using a rat model found significant differences at the time of diabetes onset in the bacterial communities responsible for type 1 diabetes modulation. We hypothesized that type 1 diabetes in humans could also be linked to a specific gut microbiota. Our aim was to quantify and evaluate the difference in the composition of gut microbiota between children with type 1diabetes and healthy children and to determine the possible relationship of the gut microbiota of children with type 1 diabetes with the glycemic level.


A case-control study was carried out with 16 children with type 1 diabetes and 16 healthy children. The fecal bacteria composition was investigated by polymerase chain reaction-denaturing gradient gel electrophoresis and real-time quantitative polymerase chain reaction.


The mean similarity index was 47.39% for the healthy children and 37.56% for the children with diabetes, whereas the intergroup similarity index was 26.69%. In the children with diabetes, the bacterial number of Actinobacteria and Firmicutes, and the Firmicutes to Bacteroidetes ratio were all significantly decreased, with the quantity of Bacteroidetes significantly increased with respect to healthy children. At the genus level, we found a significant increase in the number of Clostridium, Bacteroides and Veillonella and a significant decrease in the number of Lactobacillus, Bifidobacterium, Blautia coccoides/Eubacterium rectale group and Prevotella in the children with diabetes. We also found that the number of Bifidobacterium and Lactobacillus, and the Firmicutes to Bacteroidetes ratio correlated negatively and significantly with the plasma glucose level while the quantity of Clostridium correlated positively and significantly with the plasma glucose level in the diabetes group.


This is the first study showing that type 1 diabetes is associated with compositional changes in gut microbiota. The significant differences in the number of Bifidobacterium, Lactobacillus and Clostridium and in the Firmicutes to Bacteroidetes ratio observed between the two groups could be related to the glycemic level in the group with diabetes. Moreover, the quantity of bacteria essential to maintain gut integrity was significantly lower in the children with diabetes than the healthy children. These findings could be useful for developing strategies to control the development of type 1 diabetes by modifying the gut microbiota.
Abstract here
Full paper here



Steve P said...

New details and research are so important with any disease and there is so much about how our bodies react with the various enzymes, bacteria etc that we do not know about or do not have enough research papers available. Type 1 and Type 2 Diabetes are two very different illnesses and it is fascinating to see the difference in the 'gut flora' which is now coming more to the fore front of research. This cannot be a bad thing, the more that is known and then understood about the bodies reactions can only help in the understanding of Type 1 diabetes and other illnesses as one piece of knowledge so often leads on to others
Very good piece this
Thank you

Anonymous said...

I know that some believe that ALL disease starts in the stomach.
I'm currently looking a little into oral health, and the benefits of 'oil-pulling.'

The stomach of course is not a million miles away from the mouth, so heading the bacteria off at the pass may help.

Thanks for this

Geoff J

Lowcarb team member said...

Thanks for your comment Geoff.

Regards Eddie

Lowcarb team member said...

Hi Steve

Thanks for your time.

Regards Eddie

Anonymous said...

More to read about the effect of how gut microbiota can and does have an affect on illnesses. We are what we eat but we do not always know what we are eating these days. Even the soils that foods are grown on are not the same as they were decades ago with the huge increase of fertilisers and other chemical compounds that are widely used. Perhaps it is best to eat organic if you can afford to.

Paul B

Anonymous said...

I'm hearing what you are saying here Paul, soils are very different to how they were years ago, they are not rested for one thing and of course the chemicals that are put on them are transferred. If you can afford to pay a little more for your food then I certainly think it may help to buy organic, if you can't it is very important to make sure food is as clean as can be. News about gut flora and how the body inter-acts gives food for thought, no pun intended.