Please check out our website www.lowcarbdiabetic.co.uk We created and maintain this site without any help from anyone else. In doing so, we do not receive direct or indirect funding from anyone. We do not accept money or favours to manipulate the evidence in any way. Please visit our Low Carb food and recipe blog www.lowcarbdietsandrecipes.blogspot.com
Wednesday, 15 February 2012
Inflammation markers and metabolic characteristics of subjects with one-hour plasma glucose levels !
Objective: To assess the association of 1-h plasma glucose (1hPG) and inflammation with normal glucose tolerance (NGT) and pre-diabetes (pre-DM).
Research Design And Methods: A cohort of 1062 subjects was enrolled. After oral glucose load (OGTT), we compared NGT and pre-DM subjects above and below the 1hPG cut point (155 mg/dl). Fibrinogen and leucocytes count (WBC) for subclinical inflammation, lipid ratios, insulin sensitivity (Matsuda Index), were determined.
Results: NGT and pre-DM patients 1hPG>155 mg/dl showed a significant increase of inflammatory markers and lipid ratios (for all, p<0.05). In age-sex-BMI-adjusted analysis, 1hPG is associated with a significant higher WBC count and fibrinogen (p<0.05). Patients with elevated 1hPG showed a highly significant lower insulin sensitivity than subjects below 1hPG (p<0.01).
Conclusions: Elevated 1hPG in NGT and pre-DM subjects is associated to subclinical inflammation, high lipid ratios and insulin resistance. Therefore, 1hPG >155 mg/dl could be considered a new “marker” for cardiovascular risk.