Vitamin D Supplementation Improves Cognitive Function Through Reducing Oxidative Stress Regulated by Telomere Length in Older Adults with Mild Cognitive Impairment: A 12-Month Randomized Controlled Trial
AbstractBackground: Cognitive decline in older adults is a serious public health problem today. Association between vitamin D supplementation and cognition remains controversial.
Objective: To determine whether a 12-month vitamin D supplementation improves cognitive function in elderly subjects with mild cognitive impairment (MCI), and whether it is mediated through the mechanism in which telomere length (TL) regulate oxidative stress.
Methods: This was a double-blind, randomized, placebo-controlled trial in Tianjin, China. Participants were all native Chinese speakers aged 65 years and older with MCI. 183 subjects were randomized to an intervention group (vitamin D 800 IU/day, n = 93) or a placebo group (the matching starch granules, n = 90), and followed up for 12 months. Tests of cognitive function and mechanism-related biomarkers were evaluated at baseline, 6 months, and 12 months.
Results: Repeated-measures ANOVA showed substantial improvements in the full scale intelligence quotient (FSIQ), information, digit span, vocabulary, block design, and picture arrangement scores in the vitamin D group over the placebo group (p < 0.001). Leukocyte TL was significantly higher, while serum 8-OXO-dG, OGG1mRNA, and P16INK4amRNA revealed greater decreases in the vitamin D group over the placebo group (p < 0.001). According to mixed-model repeated-measures ANOVA analysis, vitamin D group showed a significant enhancement in the FSIQ score for 12 months compared with the control (estimate value = 5.132, p < 0.001).
Conclusion: Vitamin D supplementation for 12 months appears to improve cognitive function through reducing oxidative stress regulated by increased TL in order adults with MCI. Vitamin D may be a promising public health strategy to prevent cognitive decline.
Keywords: Cognitive performance; oxidative stress; telomere; vitamin D.
Words above from here
h/t Marks Daily Apple here
Related Posts
Why you need more Vitamin D in the winter - hereSome Effective Ways to Increase Your Vitamin D Levels - here
Recently Reported
Scientists believe a lack of Vitamin D may increase the risk of catching Covid-19 - hereI know many do take additional Vitamin D, do you, what are your thoughts?
Dear reader, this blog is presented in a magazine style - we hope something for everyone. You will find a variety of articles, studies, thoughts, photographs, cartoons, music and recipes! However, not all the recipes ideas featured in this blog may be suitable for you. If you may have any food allergies, or underlying health issues these must always be taken into account. If you are a diabetic and not sure how certain foods may affect your blood sugars, test is best, i.e. use your meter.
All the best Jan
All the best Jan
21 comments:
I do take a low dose vitamin D pill and drink milk.
I take Vitamin D each day and hope fervently to postpone my cognitive decline.
...I did take a Vitamin D supplement and after a test my doctor said that I didn't need it.
I take vitamin D especially in the winter months and I eat lots of foods rich in vitamin D too.
Gracias siempre por las buenas informaciones, y por vuestras visitas. Cuidaros.
Un abrazo.
All the good foods we eat, good for the brain and soul...xxx
I don't take any D supplement - doctor says I don't need to.
I don't but...on the other hand, my diet is rich in vitamin D.
Good article. Thanx.
God bless.
Laura. M said...
Gracias siempre por las buenas informaciones, y por vuestras visitas. Cuidaros.
Un abrazo
Google translate
Thank you always for the good information, and for your visits. Take care of yourself.
A hug.
My diet is rich in Vitamin D and I get enough sun. Yet, my vitamin D level was rock bottom. So, I take 50K mg once a week and now the doctor has upped it to once a day at a lower level but still twice the original pill.
Interesting to read.
Last blood test I had showed I had plenty of Vit D, so I'm lucky :)
Great info and post.
I have to take a daily dose of Vitamin D, my doctor keeps an eye on my levels.
I have been really low before. Take care, enjoy your day!
Thanks for the article Jan. I've actually never had my levels tested, but living in Australia I get enough sun, but nice to know that it helps slow mental decline.
My first time visiting here. I take a vitamin D supplement and have for years. I've never discussed it with my doctor, but now I think I will.
It's difficult getting enough sun these days in Canada! We're at -9 this morning!
I am outside most days and letting the sun give me the D I need...but it's not enough I can add some of these foods to my diet...Thank you Jan.
Good to know about vitamin D - and thanks for the article, list of foods, etc.
I take 2,000 units a day and have for sometime after I tested low. I have no idea if it helps anything but my level, but it's easy enough to do!
Wonderful post. Hubs and I have been taking Vit D since the covid outbreak.xxx
We always have some Vitamin D in the house!
Post a Comment