Investigators studied the potential relationships between vitamin D biomarkers, diabetes, and obesity in two cohorts in a cross-sectional study. The first cohort included 118 patients with a wide range of BMI who had normal carbohydrate metabolism, prediabetes, or diabetes. The second cohort included 30 obese patients with normal or impaired carbohydrate metabolism.
Vitamin D levels were correlated negatively with insulin resistance, but not BMI. Obese participants who had normal carbohydrate metabolism had higher levels of vitamin D than those with diabetes. Likewise, lean participants with diabetes or impaired glucose metabolism were more likely to have low levels of vitamin D.
The study suggests that both low vitamin D levels and obesity contribute to diabetes and other metabolic disorders. To reduce these risks, the investigators suggest people adhere to a healthy diet and get enough outdoor activity to stimulate natural vitamin D production.
Vitamin D deficiency is more closely associated with carbohydrate metabolism than with obesity, says a new study.
In a study of two cohorts, 25(OH)D levels were significantly lower in prediabetes and diabetes patients than in normoglycemic patients (P<0.05). The research was published on Feb. 23 in The Journal of Clinical Endocrinology and Metabolism.
"The major strength of this study is that it is the first cross-sectional study to compare serum 25(OH)D simultaneously between a wide range of BMI values taking into account..."