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Tuesday 10 April 2012

Sugar Production Switch in Liver May Offer Target for New Diabetes Therapies.

In a paper published April 8 in Nature, the scientists say that controlling the activity of these two molecules, which work together to allow more or less glucose production, could potentially offer a new way to lower blood sugar to treat insulin-resistant type II diabetes. They showed, through an experimental technique, that this was possible in diabetic mice.

"If you control these switches, you can control the production of glucose, which is really at the heart of the problem of type 2 diabetes," says Professor Marc Montminy, head of Salk's Clayton Foundation Laboratories for Peptide Biology.

"But in insulin-resistant type II diabetic individuals, the CRTC2 switch is turned on too strongly because the insulin signal is not getting through," Montminy says. "As a result, the liver produces too much glucose and the level of glucose in the blood stream is too high. Over a period of 10 to 20 years, the abnormal elevation of glucose leads to chronic complications including heart disease, blindness and kidney failure."


Anonymous said...

Those ruddy mice again. For someone against pharma it's odd you post this research, perhaps it might be of some benefit to you

Carb O'Phile said...

How is this different from a study performed by "some bloke in a garden shed with diabetic rats"?

Lowcarb team member said...

Carbo, I am chuffed to learn rumours of your demise were greatly exaggerated. You are correct, I don’t have much faith in mice and rat studies. You must appreciate, this post was not being used as a way to spread fear and alarm amongst the newly diagnosed, as the clique often resort to.

How’s the weight loss going ? Please feel free to contact me if you feel I can be of assistance.


Anonymous said...

I must say cugila fits in very well with all the other loonies on carbo's blog, he must feel at home there, it's like one happy asylum!

Lowcarb team member said...

Carb O'Phile said...
How is this different from a study performed by "some bloke in a garden shed with diabetic rats"?

It's my ole buddy tubolard again, greeting tubs!

Yes this is a rodent study but we don't make any claims about, it's an article in the news and until a study is is done on humans it offers a bit of hope but at this time that's all it is.

On the other hand

This is an example of a rodent study posted by your friend? catherinecherub/butterfly,this was aimed at us lowcarbers of course, warning of the dangers of a high fat diet. That the diet was not low carb (Weintraub adds that the diet fed to the mouse models was not unlike the diets consumed by many Americans.) the cherub neglected to mention that!

You can see the thread here and also the clique at work!

Lowcarb team member said...

Another thing for anyone that's not seen the formula for research mouse chow it can be found here;
And here;

How true the following is:

“The deleterious effects of fat have been measured in the presence of high carbohydrate. A high fat diet in the presence of high carbohydrate is different than a high fat diet in the presence of low carbohydrate.” Richard Feinman, PhD