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Thursday 26 April 2012

Vitamin D Levels Predict All-Cause and Cardiovascular Disease Mortality in Subjects With the Metabolic Syndrome !

The Ludwigshafen Risk and Cardiovascular Health (LURIC) study


OBJECTIVE Optimal vitamin D levels are associated with reduced cardiovascular and all-cause mortality. We investigated whether optimal 25-hydroxyvitamin D (25[OH]D) is protective in individuals with the metabolic syndrome.   

RESEARCH DESIGN AND METHODS The Ludwigshafen Risk and Cardiovascular Health (LURIC) study is a cohort study of subjects referred for coronary angiography between 1997 and 2000, from which 1,801 with the metabolic syndrome were investigated. Mortality was tracked for a median of 7.7 years. Multivariable survival analysis was used to estimate the association between 25(OH)D levels and mortality.

 RESULTS Most subjects (92%) had suboptimal levels of 25(OH)D (<75 nmol/L), with 22.2% being severely deficient (<25 nmol/L). During follow-up, 462 deaths were recorded, 267 (57.8%) of which were cardiovascular in origin. After full adjustment, including the metabolic syndrome components, those with optimal 25(OH)D levels showed a substantial reduction in all-cause (hazard ratio [HR] 0.25 [95% CI 0.13–0.46]) and cardiovascular disease mortality (0.33 [0.16–0.66]) compared with those with severe vitamin D deficiency. For specific cardiovascular disease mortality, there was a strong reduction for sudden death (0.15 [0.04–0.63]) and congestive heart failure (0.24 [0.06–1.04]), but not for myocardial infarction. The reduction in mortality was dose-dependent for each of these causes. 

CONCLUSIONS Optimal 25(OH)D levels substantially lowered all-cause and cardiovascular disease mortality in subjects with the metabolic syndrome. These observations call for interventional studies that test whether vitamin D supplementation provides a useful adjunct in reducing mortality in these subjects. 



Lowcarb team member said...

Does anyone remember the poster who highlighted the importance of vitamin D3 om a number of years ago? He was banned!


Lowcarb team member said...

Oops an Ally, jokar moment there. Ommmmm


Lowcarb team member said...

That would be Hutchinson, are you having a senior moment John?


J. Hancock said...

And why was he banned? And by whom?

Shirley knot for promoting the benefits of vitamin D to the members of DCUK? Or was it because he wasn't completely honest about the pyramid scheme he was deliberately inviting members of that forum to join? Or was it because he was unapologetically upsetting parents of T1s by blaming their so-called vitamin D deficiency for causing their child's condition? Or perhaps it might have been a combination of the latter two and not because of his profound belief in the benefits of topless sunbathing in African women? Alas, a lack of perfect recall appears to be affecting someone's memory!

Shirley Knot said...

Please note I have no knowledge of J Hancock, I am a respectable married lady and can assure you we have never met.


Lowcarb team member said...

"pyramid scheme"

Hi J Hancock can you enlighten us about this, a link perhaps. I do remember was directing members to buy D from iHerb and giving his promo code, yes he'd gain by this but it's not a crime is it.


Don't Call Me Shirley

Anonymous said...

J Hancock - Upsetting parents of Type 1's is bad unless people don't get upset by knowledge.

This study is pretty amazing in terms of the reduction in the development of Type 1 diabetes amongst the group of children who took supplements.